CultureOne
Alfa Laval CultureOne is a premium range of separators designed for single-use cell harvesting in biopharmaceutical processing. With proven innovations for gentle product treatment and increased yield, CultureOne provides unmatched separation efficiency for high-density cell cultures.
Premium and proven centrifuges for improved single-use biopharma production
- Proven product recovery yields up to 99%
- Easily scalable to larger Alfa Laval stainless steel separators
- 50 to 80% less water, energy, and cleaning agents compared to filter-based harvesting methods – with only a fraction of plastics
- Faster harvesting at large volumes and high cell densities
- Compact design and fast batch changeover
With CultureOne separators, you can get the most out of your harvested product. Our separators deliver higher product yields than other single-use technology, with yields up to 99%. The Hermetic Design CultureOne separator ensures gentle treatment to reduce cell lysis and avoid foaming – resulting in easier downstream purification. With Alfa Laval Spinsert, our patented single-use disc stack, you get easy set up and replacement, ensuring fast batch changeover.
Our superior separation performance leads to a clear centrate with very low remaining solids content. This minimizes the need for secondary filtration – greatly reducing the ecological footprint.
CultureOne separators are easy to operate, as stand-alone units or connected to a centralized system. The automation and connectivity provide complete data integrity, compliant with 21 CFR Part 11.
Did you know?
With the Alfa Laval CultureOne range, you can scale your single-use bioprocess easily and efficiently. Our bioprocess equipment and automation solutions help you avoid data and time losses. They also meet GMP requirements for your manufacturing facility and ensure system validation, data integrity and product quality. Plus, Alfa Laval experts can support you during commissioning, validation, and qualification for GMP production. Contact us today to learn more.
The CultureOne range
CultureOne™ separators enhance efficiency in single-use bioprocessing, increasing product recovery and streamlining workflows from R&D to production scale.
Watch: How CultureOne™ enhances cell harvesting in biopharma
Curious about the CultureOne™ separators? In this short animation, you can explore how these advanced systems support cell harvesting.
CultureOne Primo
- Processing capacity: 240 litres/hour
- Product recovery yield: Up to 99%
CultureOne Maxi
- Processing capacity: 720 litres/hour
- Product recovery yield: Up to 99%
* Capacity figures for fed-batch mammalian cell culture materials. Actual process performance is a function of individual material characteristics.
Main facts about CultureOne™
Improving yields at every scale
The CultureOne separation platform is designed to maximize the potential of every cell culture, delivering unparalleled yields, ensuring product quality with utmost security, and minimizing additional lysis. The range ensures consistent performance throughout the transition from R&D to full-scale production, allowing for seamless scalability.
Developed with the industry to meet the most challenging demands
The CultureOne separation system was developed in close collaboration with leading biopharmaceutical manufacturers. Its unique performance has been verified in a wide range of processes to ensure it can meet ever-changing demands.
Less waste in single-use processing
With CultureOne separators, you can reduce the amount of water, chemicals, and plastic consumables required for single-use biopharma processing by 50 to 80%. The result is lower costs and added sustainability.
Services
장비 성능 확장
일피리빌의 글로벌 서비스 네트워크는 어디서나 필요할 때 부품 및 전문 기술을 지원합니다. 탁월한 가동 시간, 가용성, 최적화를 보장하여 고객이 안심하고 장비를 활용해 투자 수익을 극대화할 수 있도록 도와드립니다. 고객과 협력하여 당사의 서비스를 성능 계약 에 통합해 예측 가능하고 걱정 없이 사용할 수 있도록 노력하겠습니다.
Are you considering single-use centrifugation?
Why switch to single-use processing?
A single-use separation system secures patient safety by eliminating the risk of cross-contamination between batches. Single-use processing also enables a reduced footprint and increased flexibility, with no need for sterilization: empowering manufacturers to bring new treatments to market faster than ever before.
A better harvest with centrifugal separation
Many single-use harvesting systems cannot efficiently separate high-density cell cultures. The resulting product loss dramatically impacts the productivity and profitability of biopharmaceutical operations. CultureOne overcomes this problem by combining high-efficiency centrifugal separation with secure and convenient single-use processing.
Safety and quality with Spinsert™
CultureOne's performance is based on the Spinsert, a patented single-use disposable bowl and disc stack assembly – fully sterilized and ready for processing. Easy to set up and replace, it ensures fast batch changeover. In order to achieve this, Alfa Laval has integrated proven technology from stainless steel separators:
- Hermetic Design, an Alfa Laval unique design, providing low shear, higher product recovery, and foam free separation
- TopStream™ enables continuous concentrated solid ejection during separation
- UniDisc™ increases disc area for improved separation efficiency.
Proven and published performance in biopharmaceutical processing
In October 2020, BioProcess International published a study on CultureOne™ Primo, conducted with Genentech. The study demonstrated exceptional separation efficiency in cell harvesting and single-use bioprocessing, with recovery yields of up to 99%. Watch our webinar and read the whitepaper to learn more about this single-use centrifuge technology for biopharmaceutical processing.
다음 분리 솔루션을 테스트, 검증 및 확장하세요.
생산 라인을 업그레이드하든 컨셉 증명을 실행하든 알파라발은 올바른 분리기 솔루션을 자신있게 선택할 수 있도록 도와드립니다. 알파라발의 테스트 센터 중 한 곳에서 상담 및 시험을 예약하시거나 현장 테스트를 위한 장치를 임대하시려면 연락주시기 바랍니다.
Get the answers you need
Visit the Q&A section for answers to some of the most common questions about CultureOne and its potential – or send your question to our experts.